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Chronic Fatigue

Chronic fatigue syndrome (CFS) is a disorder that causes extreme fatigue. This is not the kind of tired feeling that goes away after you rest. Instead, it lasts a long time and limits your ability to do ordinary daily activities.

Symptoms of CFS include fatigue for 6 months or more and experiencing other problems such as muscle pain, memory problems, headaches, pain in multiple joints, sleep problems, sore throat and tender lymph nodes. Since other illnesses can cause similar symptoms, it is hard to diagnose. No one knows what causes CFS. It is most common in women in their 40s and 50s, but anyone can have it. It can last for years. There is no cure for it, so the goal of treatment is to improve symptoms. Medicines may treat pain, sleep disorders and other problems. (Source:Centers for Disease Control and Prevention)

Studies

Polyphenol rich chocolate improves the symptoms of this disease.

Studies with selective 5-HT-releasing agents, using prolactin or cortisol responses to stimulation, found evidence of enhanced serotonergic responses in patients with CFS. Cocoa is known to increase neurotransmitters like phenyl ethylamine, serotonin, and anandamide in the brain.

Objective

To study the effect of high cocoa polyphenol rich chocolate in patients with Chronic Fatigue Syndrome,T Sathyapalan, P Campion, S Beckett, AS Rigby & SL Atkin from the University of Hull, Hull, United Kingdom; designed a double blinded, randomised, placebo controlled fashion using high cocoa polyphenol rich chocolate in comparison to simulated iso-calorific chocolate dyed brown as placebo. Read more...

Chronic fatigue

Results

Ten patients were enrolled in the study

High cocoa Polyphenol rich chocolate improves the symptoms of this disease.

Anecdotally, two patients were able to return back to work after having had their symptoms for a 2 year period and continued on high cocoa polyphenol rich chocolate.


A study of which 5 patients completed both arms. The Chandler Fatigue Scale score improved significantly after 8 weeks of the high cocoa polyphenol rich chocolate phase (32.6 vs. 22.0 p value 0.012) and, interestingly, fell significantly when patients were given simulated iso-calorific chocolate (25.3 vs. 28.6 p value 0.026).

The residual function, as assessed by the London Handicap scale, also improved significantly after the active phase (0.485 vs. 0.628 p value 0.018). The mean weight before and after the placebo arm were also unchanged (73.43 kg vs. 73.85 kg, respectively p value 0.345).

Conclusion

High cocoa polyphenols rich chocolate 15 g three times daily improved tiredness and function in patients with chronic fatigue syndrome over a period of 8 weeks compared to simulated iso-calorific chocolate.





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